Clozapine N-oxide dihydrochloride

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Clozapine N-oxide dihydrochloride

CAS No. : 2250025-93-3

Biological Activity:Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

Research Area:Neurological Disease

Targets:Drug Metabolite|Dopamine Receptor|mAChR

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