4-Hydroperoxy Cyclophosphamide-d4

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4-Hydroperoxy Cyclophosphamide-d4

CAS No. : 1246816-71-6

Biological Activity:4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[2].

Research Area:Inflammation/Immunology

Targets:Drug Metabolite|DNA Alkylator/Crosslinker|Reactive Oxygen Species|Apoptosis

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