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CAS No. : 1316755-16-4
Biological Activity：Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
Research Area：Neurological Disease|Endocrinology
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Clinical Compound Library;Peptidomimetic Library;Drug Repurposing Compound Library;Endocrinology Compound Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:Saralasin;A81988;EMD 66684;TD-0212;Angiotensin I/II (1-6) (TFA);YS-49;TRV055;TRV056;H-Val-Pro-Pro-OH TFA;Tranilast sodium;Angiotensin amide;L162389;L-159282;CGP48369;Elisartan;Pratosartan;TRV-120027 TFA;SL910102
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