Tag: Modulator

For research use only. We do not sell to patients. Ozanimod hydrochloride CAS No. : 1618636-37-5 Biological Activity：Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 […]

For research use only. We do not sell to patients. MIF-1 TFA CAS No. : 35240-69-8 Biological Activity：MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects of morphine and stress-induced analgesia […]

For research use only. We do not sell to patients. P-gp inhibitor 4 CAS No. : 2652001-05-1 Biological Activity：P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells. Research Area：Cancer Targets：P-glycoprotein […]

For research use only. We do not sell to patients. H3 receptor-MO-1 CAS No. : 1240914-03-7 Biological Activity：H3 receptor-MO-1 is a modulator of histamine H3 receptor. Research Area：Endocrinology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;Diphenhydramine;ABT-239;Ketotifen fumarate;Ranitidine;Cetirizine;Diphenylpyraline hydrochloride;Loratadine-d5;Phenyltoloxamine;Ritanserin;BMY-25271;FRG8701;Mecamylamine hydrochloride;Cimetidine sulfoxide;Brompheniramine maleate;Tecastemizole;Famotidine-13C,d3;Bromazine-d6 hydrochloride Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  […]

For research use only. We do not sell to patients. VU6010572 CAS No. : 2126784-39-0 Biological Activity：VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[2]. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD 9272;mGluR2 antagonist 1;ABP688;FTIDC;MPPG;L-AP3;VU6001966;VU0155041 sodium;VU 0364439;trans-ACPD;AZD-8529 […]

For research use only. We do not sell to patients. Aβ42-IN-1 free base CAS No. : 2434633-17-5 Biological Activity：Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 […]

For research use only. We do not sell to patients. MitoTEMPO hydrate CAS No. : 1569257-94-8 Biological Activity：Mito-TEMPO is a mitochondria-targeted antioxidant that possesses superoxide and alkyl radical scavenging properties. Mito-TEMPO helps protect against oxidative damage to the mitochondria. Research Area：Others Targets：Mitochondrial Metabolism Related Small Molecules:MitoTam bromide, hydrobromide;NL-1;Thiabendazole-d4;D-Histidine;Mito-apocynin (C2);Fumarate hydratase-IN-2 sodium salt;Schaftoside;Daidzin;Azemiglitazone;Tempo;Idebenone;Menadiol;CTPI-2;Senecionine acetate;Antimalarial agent 14;Mito-apocynin […]

For research use only. We do not sell to patients. Raloxifene 4′-glucuronide CAS No. : 182507-22-8 Biological Activity：Raloxifene 4′-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4′-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4′-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [2]. Raloxifene is a selective estrogen receptor modulator. […]

For research use only. We do not sell to patients. Cariprazine-d6 hydrochloride CAS No. : 2714418-94-5 Biological Activity：Cariprazine-d6 (RGH188-d6) hydrochloride is the deuterium labeled Cariprazine hydrochloride. Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 […]

For research use only. We do not sell to patients. VU0453379 CAS No. : 1638646-27-1 Biological Activity：VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM. Research Area：Metabolic Disease Targets：GCGR Related Small Molecules:BETP;GLP-1R agonist 4;PF-06291874;Utreglutide;TT-OAD2;Efocipegtrutide;GLP-1 receptor agonist 2;NNC-0640;Cochinchinenin C;{Val1}-Exendin-3/4;GLP-1(28-36)amide TFA;Exendin-4 […]