Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Fedratinib hydrochloride hydrate CAS No. : 1374744-69-0 Biological Activity：Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 […]

For research use only. We do not sell to patients. Cinchonine CAS No. : 118-10-5 Biological Activity：Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Research Area：Cancer Targets：Parasite|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Natural Product Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. NF-κB-IN-4 Biological Activity：NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. […]

For research use only. We do not sell to patients. EGFR/HER2/TS-IN-1 CAS No. : 2444363-11-3 Biological Activity：EGFR/HER2/TS-IN-1 (Compound 4d) is an EGFR, HER2 and TS (Thymidylate synthase) inhibitor with IC50 values of 0.203, 0.088 and 0.168 μM against EGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cell apoptosis. Research Area：Cancer Targets：EGFR|Thymidylate Synthase|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. FLT3-IN-14 CAS No. : 2620551-45-1 Biological Activity：FLT3-IN-14 is a potent FLT3 inhibitor with IC50s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor […]

For research use only. We do not sell to patients. Estramustine phosphate CAS No. : 4891-15-0 Biological Activity：Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which […]

For research use only. We do not sell to patients. Malabaricone B CAS No. : 63335-24-0 Biological Activity：Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[2][3]. Research Area：Cancer|Infection|Metabolic Disease Targets：Glucosidase|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive […]

For research use only. We do not sell to patients. Tirabrutinib hydrochloride CAS No. : 1439901-97-9 Biological Activity：Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton’s Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride irreversibly and covalently binds to BTK and inhibits aberrant B cell receptor […]

For research use only. We do not sell to patients. Cucurbitacin IIa CAS No. : 58546-34-2 Biological Activity：Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells. Research Area：Cancer Targets：Survivin|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive […]

For research use only. We do not sell to patients. SN-38 CAS No. : 86639-52-3 Biological Activity：SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[2][3][4]. Research Area：Cancer Targets：Topoisomerase|Autophagy|ADC Cytotoxin Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound […]