Tag: Antagonist

For research use only. We do not sell to patients. CXCR2 antagonist 3 CAS No. : 2647464-92-2 Biological Activity：CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces […]

For research use only. We do not sell to patients. TCN 213 CAS No. : 556803-08-8 Biological Activity：TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in […]

For research use only. We do not sell to patients. Ipratropium bromide CAS No. : 22254-24-6 Biological Activity：Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with IC50s of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide relaxes smooth muscle, can be used in the research for […]

For research use only. We do not sell to patients. FR252384 CAS No. : 447405-11-0 Biological Activity：FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM. Research Area：Endocrinology Targets：Neuropeptide Y Receptor Related Small Molecules:[D-Trp34]-Neuropeptide Y TFA;Pancreatic Polypeptide, human;Peptide YY (PYY), human;JNJ-5207787;[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA;GR231118 TFA;Neuropeptide Y (human);RF9 hydrochloride;M1145;Galanin Receptor Ligand M35 TFA;Neuropeptide Y […]

For research use only. We do not sell to patients. CI-988 CAS No. : 130332-27-3 Biological Activity：CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC50 of 1.7 nM for mouse cortex CCK2. CI-988 shows >1600-fold selectivity for CCK2 over CCK1 receptor. CI-988 has anxiolytic and anti-tumor effects[2][3]. […]

For research use only. We do not sell to patients. DH97 CAS No. : 220339-00-4 Biological Activity：DH97 is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. DH97 shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. DH97 can inhibit […]

For research use only. We do not sell to patients. Idazoxan-d4 hydrochloride CAS No. : 1329834-12-9 Biological Activity：Idazoxan-d4 (RX 781094-d4) hydrochloride is the deuterium labeled Idazoxan hydrochloride. Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). […]

For research use only. We do not sell to patients. Chrodrimanin B CAS No. : 132196-54-4 Biological Activity：Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin […]

For research use only. We do not sell to patients. Pizotifen malate CAS No. : 5189-11-7 Biological Activity：Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. Research Area：Neurological Disease Targets：5-HT Receptor Related Small Molecules:F 13714;Mosapride-d5;Nuciferine;Renzapride;LY 344864 racemate;Harmine hydrochloride;Valerenic acid;Arotinolol;Melitracen-d6 hydrochloride;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Tetrahydro-β-carboline;CP-809101;Volinanserin-d4 hydrochloride;Masupirdine free base;BRL-15572 dihydrochloride;LY393558;Brexpiprazole […]

For research use only. We do not sell to patients. Phentolamine-d4 hydrochloride CAS No. : 1346599-65-2 Biological Activity：Phentolamine-d4 (Phentolamine-d4) hydrochloride is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be […]