Tag: Antagonist

For research use only. We do not sell to patients. Glucagon receptor antagonists-5 CAS No. : 2200274-63-9 Biological Activity：Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM). Research Area：Metabolic Disease Targets：GCGR Related Small Molecules:BETP;GLP-1R […]

For research use only. We do not sell to patients. EP2 receptor antagonist-1 CAS No. : 848920-08-1 Biological Activity：EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist. EP2 receptor antagonist-1 shows anti-inflammatory effects. Research Area：Inflammation/Immunology Targets：Prostaglandin Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound […]

For research use only. We do not sell to patients. Mitiglinide-d8 calcium hydrate Biological Activity：Mitiglinide-d8 calcium hydrate (KAD-1229-d8) is the deuterium labeled Mitiglinide calcium hydrate. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide […]

For research use only. We do not sell to patients. SB228357 CAS No. : 181629-93-6 Biological Activity：SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects[2]. Research Area：Neurological Disease Targets：5-HT Receptor Related Small Molecules:F 13714;Mosapride-d5;Nuciferine;Renzapride;LY 344864 […]

For research use only. We do not sell to patients. KAAD-Cyclopamine CAS No. : 306387-90-6 Biological Activity：KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist. Research Area：Cancer Targets：Smo Related Small Molecules:Saikosaponin B1;MRT-10;LEQ506;RL-0070933;20(S)-Hydroxycholesterol;Sonidegib;PF-5274857 hydrochloride;MRT-83 hydrochloride;TPB15;CUR61414;SANT-1;SAG-d3;SMANT hydrochloride;BMS-833923;SMO-IN-2;SMO-IN-1;IHR-1;Purmorphamine (GMP);IHR-Cy3;MRT-14;MK-4101;SAG hydrochloride;DY131 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  […]

For research use only. We do not sell to patients. LPA1 receptor antagonist 1 CAS No. : 1396006-71-5 Biological Activity：LPA1 receptor antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC50 of 25 nM. Research Area：Infection|Inflammation/Immunology Targets：LPL Receptor Related Small Molecules:GSK2018682;Ozanimod hydrochloride;BMS-986020 sodium;S1p receptor agonist 2;ONO-9780307;Siponimod hemifumarate;S1P2 antagonist 1;S1P1 agonist III;Ceralifimod;Ki16425;H2L […]

For research use only. We do not sell to patients. A 1120 CAS No. : 1152782-19-8 Biological Activity：A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[2]. Research Area：Metabolic Disease Targets：Others Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. a-Helical Corticotropin Releasing Factor (9-41) CAS No. : 99658-03-4 Biological Activity：α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[2]. Research Area：Inflammation/Immunology Targets：CRFR Related Small Molecules:Stresscopin-related peptide (human);Sauvagine;CRF(6-33)(human) TFA;NBI-27914;Urocortin III, […]

For research use only. We do not sell to patients. UFP-101 TFA Biological Activity：UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect[2]. Research Area：Neurological Disease Targets：Opioid Receptor […]

For research use only. We do not sell to patients. GLP-1(9-36)amide CAS No. : 161748-29-4 Biological Activity：GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor[2]. Research Area：Metabolic Disease Targets：GCGR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound […]