Tag: Antagonist

For research use only. We do not sell to patients. Valategrast hydrochloride CAS No. : 828271-96-1 Biological Activity：Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[2]. Research Area：Inflammation/Immunology Targets：Integrin Related Small Molecules:GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl ester sulfate;HSDVHK-NH2;Lifitegrast […]

For research use only. We do not sell to patients. Ladarixin sodium CAS No. : 865625-56-5 Biological Activity：Ladarixin sodium (DF 2156A) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin sodium can be used for the research of COPD and asthma. Research Area：Infection|Inflammation/Immunology Targets：CXCR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical […]

For research use only. We do not sell to patients. Dicentrine CAS No. : 517-66-8 Biological Activity：Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates. Research Area：Endocrinology Targets：Adrenergic Receptor Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. NAB-14 CAS No. : 1237541-73-9 Biological Activity：NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier. Research Area：Neurological […]

For research use only. We do not sell to patients. Phentolamine mesylate CAS No. : 65-28-1 Biological Activity：Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, […]

For research use only. We do not sell to patients. GPR52 antagonist-1 CAS No. : 1239987-91-7 Biological Activity：GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Research Area：Neurological Disease Targets：Others Related […]

For research use only. We do not sell to patients. Protease-Activated Receptor-1 antagonist 1 Biological Activity：Protease-Activated Receptor-1 antagonist 1 (Compound 13) is a protease-activated receptor-1 (PAR-1) antagonist with the IC50 of 3 nM by FLIPR technology. Protease-Activated Receptor-1 antagonist 1 can be used for the research of thrombotic cardiovascular, myocardial infarction, and peripheral arterial disease. Research […]

For research use only. We do not sell to patients. Mu opioid receptor antagonist 1 Biological Activity：Mu opioid receptor antagonist 1 (compound 19) is a selective and orally active μ opioid receptor (MOR) ligand with an Ki value of 0.58 nM and an EC50 of 1.15 nM. Orally administrating with Mu opioid receptor antagonist 1 […]

For research use only. We do not sell to patients. Cyclobenzaprine hydrochloride CAS No. : 6202-23-9 Biological Activity：Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Target: 5-HT Receptor 2A Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine hydrochloride was thought […]

For research use only. We do not sell to patients. A 71915 CAS No. : 132956-87-7 Biological Activity：A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in […]