Tag: Activator|Antagonist

For research use only. We do not sell to patients. Hexamethonium Bromide CAS No. : 55-97-0 Biological Activity：Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[2][3][4]. Research Area：Neurological Disease|Cardiovascular Disease […]

For research use only. We do not sell to patients. Rupatadine D4 fumarate CAS No. : 1795153-63-7 Biological Activity：Rupatadine D4 fumarate (UR-12592 D4 fumarate) is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 μM(rabbit platelet membranes/guinea pig cerebellum membranes)[2][3]. Research Area：Inflammation/Immunology Targets：Autophagy|Histamine Receptor Related […]

For research use only. We do not sell to patients. Fipronil-13C6 Biological Activity：Fipronil-13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach […]

For research use only. We do not sell to patients. Ulipristal acetate CAS No. : 126784-99-4 Biological Activity：Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[2]. Research Area：Endocrinology|Cancer […]

For research use only. We do not sell to patients. R 59-022 CAS No. : 93076-89-2 Biological Activity：R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[2][3][4]. Research […]

For research use only. We do not sell to patients. JTE-013 CAS No. : 383150-41-2 Biological Activity：JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively. Research Area：Cancer Targets：LPL Receptor|Apoptosis Related Screening […]

For research use only. We do not sell to patients. XCT790 CAS No. : 725247-18-7 Biological Activity：XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and […]

For research use only. We do not sell to patients. Telmisartan CAS No. : 144701-48-4 Biological Activity：Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM. Research Area：Cardiovascular Disease|Endocrinology Targets：Autophagy|Angiotensin Receptor Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. 12,14-Dichlorodehydroabietic acid CAS No. : 65281-77-8 Biological Activity：12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates […]

For research use only. We do not sell to patients. Flupirtine Maleate CAS No. : 75507-68-5 Biological Activity：Flupirtine Maleate is a brain penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties[2]. Research Area：Neurological Disease Targets：Potassium Channel|iGluR Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]