June 2026
Optimization of SARS-CoV-2 PLpro Inhibitors Through Structure-Guided Design and Functional Validation
The papain-like protease (PLpro) of SARS-CoV-2 plays a dual role in viral replication and immune evasion by cleaving viral polyproteins and host ubiquitin and ISG15 chains. Targeting PLpro offers a promising strategy for developing antiviral therapeutics. This study reports the systematic optimization of a series of PLpro inhibitors based on a structural framework derived from […]
Adsorption Mechanisms and Performance of Fe-N-RSBC for Tetracycline Removal in Aqueous Systems
The adsorption behavior of tetracycline (TC) on Fe-N-modified rice straw biochar (Fe-N-RSBC) was systematically investigated to elucidate the underlying mechanisms governing pollutant removal. The enhanced performance of Fe-N-RSBC stems from its unique physicochemical properties, including high surface area (606.62 m²/g), developed mesoporous structure, abundant functional groups, and magnetic characteristics. These features collectively contribute to a […]
Microplastic Fate and Environmental Risks in Marine Ecosystems
The degradation of biodegradable poly(butylene adipate-co-terephthalate) (PBAT) in marine environments presents a significant ecological challenge due to the formation and persistence of microplastics. This study demonstrates that PBAT generates substantially higher quantities of microplastic particles in seawater compared to freshwater, primarily due to accelerated hydrolysis under alkaline conditions. The resulting fragments exhibit distinct morphologies—long, entangled […]
A Physiology-Based Mathematical Model for the Selection of Appropriate Ventilator Controls for Lung and Diaphragm Protection
Mechanical ventilation is a critical intervention in managing acute respiratory failure, yet it carries significant risks of ventilator-induced lung injury (VILI) and diaphragm dysfunction when not properly tailored to individual patients. The challenge lies in balancing adequate gas exchange with minimal mechanical stress on the lungs and respiratory muscles. To achieve this balance, clinicians must […]
**Nanoscale Engineering of Interfacial Architecture for Enhanced Thermoelectric Performance in Organic Small-Molecule Systems**
A novel strategy for enhancing thermoelectric performance in organic small-molecule systems is demonstrated through the precise engineering of nanoscale interfacial architecture. By leveraging a vapor-solid reaction between copper phthalocyanine (CuPc) and iodine, a series of CuPc/CuPcI composites were fabricated with tunable phase compositions. The key innovation lies in the controlled formation of a high density […]