May 2026
Hole-Mediated Nitric Oxide Generation for Oxygen-Independent Cancer Therapy
Nitric oxide (NO) has emerged as a potent anticancer agent due to its ability to disrupt mitochondrial function and induce apoptosis in tumor cells. However, the therapeutic efficacy of NO is often hindered by the hypoxic nature of solid tumors, where conventional NO delivery systems relying on oxygen or hydrogen peroxide face significant limitations. To […]
**Eco-Friendly Fabrication of Bio-Active Packaging from Alkali-Steam Exploded Agro-Waste Using Natural Colorants**
The growing demand for sustainable packaging solutions has prompted a shift toward biodegradable materials derived from renewable resources. In this study, we present a novel eco-friendly fabrication method for bio-active packing material using alkali-steam exploded agro-waste as the base matrix and natural colorants extracted from plant sources for functional enhancement. The process begins with the […]
A Metal-Organic Framework with Multienzyme Activity for Real-Time Electrochemical Detection of Nitric Oxide and Hydrogen Peroxide
Nitric oxide (NO) and hydrogen peroxide (H₂O₂) play pivotal roles in cellular signaling, immune defense, and redox homeostasis. Their dysregulation is implicated in inflammation, neurodegenerative diseases, cancer progression, and cardiovascular dysfunction. The ability to monitor these molecules in real time, especially in complex biological environments, is essential for both fundamental research and clinical diagnostics. However, […]
An Ultrasoft Self-Fused Supramolecular Polymer Hydrogel for Completely Preventing Postoperative Tissue Adhesion
Supramolecular polymer hydrogels have emerged as a promising class of biomaterials in biomedical applications due to their unique combination of self-healing properties, tunable mechanical strength, and thermoplastic behavior. These characteristics stem from dynamic physical interactions within the hydrogel network, including hydrogen bonding, host-guest interactions, metal-ligand coordination, and hydrophobic associations. Among these, hydrogen bonding is particularly […]
Protective Effects of Corilagin Against Renal Calcium Oxalate Crystal-Induced Oxidative Stress, Inflammation, and Apoptosis in Rats via PPAR-γ and PI3K/Akt Pathway
Kidney stones, primarily composed of calcium oxalate (CaOx), are a prevalent urological disorder affecting approximately 10–15% of the global population. Often asymptomatic in early stages, they can lead to severe complications such as renal injury and chronic kidney disease. The pathogenesis involves supersaturation of urine with CaOx, resulting in crystal nucleation, growth, and adhesion to […]
**Insights into the Lithium Diffusion Mechanism in Si/C Composite Anodes for Lithium-Ion Batteries**
Silicon-based anode materials have emerged as leading candidates for next-generation lithium-ion batteries due to their exceptionally high theoretical capacity (up to 4200 mAh/g), low cost, and natural abundance. However, their practical application is hindered by substantial volume expansion (~300%) during lithiation, which leads to mechanical degradation, loss of electrical contact, and rapid capacity fade. To […]
**Mimicking Native Enzyme Functions through Nucleoapzymes: A Structural and Functional Perspective**
The integration of catalytic units with sequence-specific aptamers has led to the emergence of a novel class of functional biocatalysts known as nucleoapzymes. These hybrid systems emulate the core functionalities of native enzymes by combining the substrate recognition capabilities of aptamers with the catalytic power of engineered molecular units. The covalent conjugation of catalysts—such as […]
Functional Immunostimulating DNA Materials: The Rising Stars for Cancer Immunotherapy
DNA has emerged as a versatile and powerful tool in the field of cancer immunotherapy, offering unique advantages due to its programmable structure, biocompatibility, and multifunctional capabilities. Among the various forms of DNA-based materials, functional immunostimulating DNA constructs are gaining increasing attention as promising candidates for modulating immune responses against tumors. These materials leverage the […]