epigenetics modulation frontier
Master of Bioactive Molecules | Inhibitors, Screening Libraries & Proteins
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme critical for the oxidation of toxic aldehydes, including acetaldehyde generated during alcohol metabolism. Its dysregulation has been linked to various diseases such…
Leukocytes and platelets are not merely passive components of the circulatory system; they are dynamic cellular sensors capable of detecting and responding to systemic metabolic and inflammatory stress. Their metabolic…
Metformin, a first-line therapy for type 2 diabetes mellitus (T2DM), exerts its primary glucose-lowering effects through hepatic AMP-activated protein kinase (AMPK) activation, leading to suppression of gluconeogenic enzyme expression. However,…
The non-receptor tyrosine kinase c-Src, commonly referred to as Src, is frequently overexpressed or hyperactivated in multiple human malignancies. Its role in colorectal cancer (CRC) has long been speculated, with…
The central amygdala (CeA) plays a critical role in mediating ethanol dependence and the anxiety-like symptoms associated with withdrawal. The GABAergic system within this region is particularly implicated in modulating…
Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles were engineered to deliver triplex-forming peptide nucleic acids (PNAs) and donor DNA for targeted gene editing of the CCR5 locus in human peripheral blood mononuclear…
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with hepatitis B virus (HBV) infection being the primary etiological factor in a significant proportion of cases. Despite advances…
The galectin-4 and galectin-6 proteins are closely related members of the galectin family, encoded by two paralogous genes—Lgals4 and Lgals6—in mice. While most mammals possess only a single Lgals4 gene,…