2-Methoxyestradiol-13C6

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2-Methoxyestradiol-13C6

Biological Activity:2-Methoxyestradiol-13C6 (2-ME2-13C6) is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[2][3][4][5][6].

Research Area:Cancer

Targets:Autophagy|Reactive Oxygen Species|Microtubule/Tubulin|Endogenous Metabolite|Apoptosis

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