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D18
CAS No. : 2230218-36-5
Biological Activity：D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2.
Research Area：Cancer|Inflammation/Immunology
Targets：PD-1/PD-L1|Toll-like Receptor (TLR)
Related Small Molecules:C29;TMX-201;RS 09;PD-1/PD-L1-IN-15;ODN 20844;TLR7/8-IN-1;TLR8 agonist 5;PD-1/PD-L1-IN 5 TFA;PD-1/PD-L1-IN-25;Sulfo-ara-F-NMN;TLR7/8 antagonist 1;Gardiquimod;PF-4878691;Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH;Pepinh-TRIF TFA;Afimetoran;PD-1/PD-L1-IN-18;Schaftoside;ODN 2088;CU-CPT22;PD-1/PD-L1-IN-22;UC-1V150;Diprovocim-X;Toripalimab;PD-1/PD-L1-IN-23;CL264
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