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SEW2871
CAS No. : 256414-75-2
Biological Activity：SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses[2].
Research Area：Metabolic Disease|Inflammation/Immunology|Neurological Disease
Targets：Akt|LPL Receptor|ERK
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Glucose Metabolism Compound Library;Antidepressant Compound Library;Human Metabolite Library;Osteogenesis Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;GSK2018682;Cyclovirobuxine D;AKTide-2T;Sennidin A;Ozanimod hydrochloride;MS98;PP2A Cancerous-IN-1;BMS-986020 sodium;S1p receptor agonist 2;ONO-9780307;1,3-Dicaffeoylquinic acid;Corynoxeine;Siponimod hemifumarate;Artemisiane E;S1P2 antagonist 1;Temuterkib;S1P1 agonist III;Artemisinin-d3;Ceralifimod;AS1949490;PI3K-IN-29;TD52 dihydrochloride;CKLF1-C27;LM22B-10;ERK5-IN-4;AT13148
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