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LP-935509

CAS No. : 1454555-29-3

Biological Activity：LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC₅₀ of 3.3 nM and a K_i of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC₅₀=14 nM) and a modest inhibitor of GAK (IC₅₀=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research.

Research Area：Infection|Inflammation/Immunology|Neurological Disease

Targets：Cyclin G-associated Kinase (GAK)|AAK1|SARS-CoV

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Neuronal Signaling Compound Library;Antiviral Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Orally Active Compound Library;Targeted Diversity Library;

Related Small Molecules:DB0614;SGC-AAK1-1;SARS-CoV-2-IN-33;GRL-0496;Grazoprevir potassium salt;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;LP-922761;MM3122;Ketotifen fumarate;SARS-CoV-2-IN-16;Thapsigargin;INSCoV-614(1B);Anti-SARS-CoV-2 Spike mAb (CR3022);GNF-2;Bemnifosbuvir hemisulfate;Kansuinine B;Proglumetacin

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