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L002

CAS No. : 321695-57-2

Biological Activity：L002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC₅₀ of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation^[2]. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment^[3].

Research Area：Cancer|Inflammation/Immunology

Targets：STAT|Histone Acetyltransferase

Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Cirsilineol;Ochromycinone;C188-9;Curcumin;STAT3-IN-10;GSK4028;CBP/p300-IN-19 hydrochloride;C188;NSC 694621;Niclosamide monohydrate;PCAF-IN-2;STAT3-IN-1;I-CBP112;STAT3 degrader-1;A-485;PM-81I;Morusin;Nifuroxazide-13C6;AS1810722;α7 nAchR-JAK2-STAT3 agonist 1;HP590;Eupalinolide K;STAT3-IN-11;TPOP146;(R)-Reticuline-d3;HAT-IN-1;JAK-IN-23

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