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KGA-2727
CAS No. : 666842-36-0
Biological Activity：KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 has antidiabetic efficacy.
Research Area：Metabolic Disease
Targets：SGLT
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Anti-diabetic Compound Library;Glycoside Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;
Related Small Molecules:Luseogliflozin;SGL5213;Tofogliflozin;Mizagliflozin;Trilobatin;TA-1887;SGLT inhibitor-1;Sotagliflozin;Phloretin;Ertugliflozin L-pyroglutamic acid;Ipragliflozin (L-Proline);LX2761;Enavogliflozin;T-1095;HSK0935;Ipragliflozin-d5;Velagliflozin;Kushenol K;Remogliflozin etabonate
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