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Doxepin Hydrochloride

CAS No. : 1229-29-4

Biological Activity：Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2^[2].
Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant^[3].
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Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system^[4].
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Doxepin has also been proposed as a protective factor against oxidative stress^[5].
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Research Area：Neurological Disease

Targets：Histamine Receptor|Cytochrome P450

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