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C25-140

CAS No. : 1358099-18-9

Biological Activity:C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.

Research Area:Inflammation/Immunology

Targets:TNF Receptor|E1/E2/E3 Enzyme

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Ubiquitination Compound Library;Pyroptosis Compound Library;Angiogenesis-Related Compound Library;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;

Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;UBE2T/FANCL-IN-1;QNZ;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;Sinulatumolin E;MD-224;DI-1859;Epobis;MX69;RG7112;Mulberroside A;Sinulatumolin D;PDE4-IN-10;Ginsenoside Rc;TIC10;Teneliximab;Teslexivir;Loganic acid 6′-O-β-D-glucoside;TRAF6 peptide;VGX-1027;AM-8735;NAcM-OPT;D-Trimannuronic acid;RO-5963;DCVC;Gamma-glutamylcysteine TFA

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